From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia.

ABSTRACT: Negative symptoms are a core clinical feature of schizophrenia that are only marginally responsive to current treatments. Recent work suggests that deficits in reinforcement learning and anticipatory responses to reward may be two mechanisms that help explain impairments in motivation in those with schizophrenia. The present study utilized a reinforcement-learning paradigm, which allowed us to examine both reward anticipation and reinforcement learning. Twenty-eight people with schizophrenia and 30 healthy controls completed a reinforcement-learning task while undergoing functional MRI. Participants with schizophrenia also completed a weeklong ecological momentary assessment protocol reporting anticipated motivation and pleasure in their daily activities. Unexpectedly, we found no signific

SUBMITTER: Moran EK 

PROVIDER: S-EPMC6776676 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature