FPR1 is the plague receptor on host immune cells.

ABSTRACT: The causative agent of plague, Yersinia pestis, uses a type III secretion system to selectively destroy immune cells in humans, thus enabling Y. pestis to reproduce in the bloodstream and be transmitted to new hosts through fleabites. The host factors that are responsible for the selective destruction of immune cells by plague bacteria are unknown. Here we show that LcrV, the needle cap protein of the Y. pestis type III secretion system, binds to the N-formylpeptide receptor (FPR1) on human immune cells to promote the translocation of bacterial effectors. Plague infection in mice is characterized by high mortality; however, Fpr1-deficient mice have increased survival and antibody responses that are protective against plague. We identified FPR1^R190W as a candidate resistance alle

SUBMITTER: Osei-Owusu P 

PROVIDER: S-EPMC6776691 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature