Alcohol Consumption and Risk of Liver Cirrhosis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

To systematically summarize the risk relationship between different levels of alcohol consumption and incidence of liver cirrhosis.

Methods

MEDLINE and Embase were searched up to March 6, 2019, to identify case-control and cohort studies with sex-specific results and more than 2 categories of drinking in relation to the incidence of liver cirrhosis. Study characteristics were extracted and random-effects meta-analyses and meta-regressions were conducted.

Results

A total of 7 cohort studies and 2 case-control studies met the inclusion criteria, providing data from 2,629,272 participants with 5,505 cases of liver cirrhosis. There was no increased risk for occasional drinkers. Consumption of one drink per day in comparison to long-term abstainers showed an inc

SUBMITTER: Roerecke M 

PROVIDER: S-EPMC6776700 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature