Identification of a 1p21 independent functional variant for abdominal obesity.

ABSTRACT:

Objectives

Aiming to uncover the genetic basis of abdominal obesity, we performed a genome-wide association study (GWAS) meta-analysis of trunk fat mass adjusted by trunk lean mass (TFM_adj) and followed by a series of functional investigations.

Subjects

A total of 11,569 subjects from six samples were included into the GWAS meta-analysis.

Methods

Meta-analysis was performed by a weighted fixed-effects model. In silico replication analysis was performed in the UK-Biobank (UKB) sample (N = 331,093) and in the GIANT study (N up to 110,204). Cis-expression QTL (cis-eQTL) analysis, dual-luciferase reporter assay and electrophoresis mobility shift assay (EMSA) were conducted to examine the functional relevance of the identified SNPs. At last, differential gene ex

SUBMITTER: Liu L 

PROVIDER: S-EPMC6776704 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature