Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect.

ABSTRACT: Preclinical studies have shown effects of chronic exposure to addictive drugs on glutamatergic-mediated neuroplasticity in frontostriatal circuitry. These initial findings have been paralleled by human functional magnetic resonance imaging (fMRI) research demonstrating weaker frontostriatal resting-state functional connectivity (rsFC) among individuals with psychostimulant use disorders. However, there is a dearth of human imaging literature describing associations between long-term prescription opioid use, frontostriatal rsFC, and brain morphology among chronic pain patients. We hypothesized that prescription opioid users with chronic pain, as compared with healthy control subjects, would evidence weaker frontostriatal rsFC coupled with less frontostriatal gray matter volume (GMV). Furthe

SUBMITTER: McConnell PA 

PROVIDER: S-EPMC6776713 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature