Minocycline reduces intracerebral hemorrhage-induced white matter injury in piglets.

ABSTRACT:

Aims

White matter (WM) injury after intracerebral hemorrhage (ICH) results in poor or even fatal outcomes. As an anti-inflammatory drug, minocycline has been considered a promising choice to treat brain injury after ICH. However, whether minocycline can reduce WM injury after ICH is still controversial. In the present study, we investigate the effect and underlying mechanism of minocycline on WM injury after ICH.

Methods

An ICH model was induced by an injection of autologous blood into the right frontal lobe of piglets. First, transcriptional analysis was performed at day 1 or 3 to investigate the dynamic changes in neuroinflammatory gene expression in WM after ICH. Second, ICH piglets were treated either with minocycline or with vehicle alone. All piglets then underwent mag

SUBMITTER: Yang H 

PROVIDER: S-EPMC6776747 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature