Accuracy of nodal staging is influenced by sidedness in colon cancer.

ABSTRACT:

Background

Adequate lymph node (LN) sampling is critical for accurate nodal staging in colon cancer (CC), particularly for T3N0 disease as current guidelines recommend considering adjuvant chemotherapy when less than 12 LNs are examined. The impact of sidedness on nodal staging accuracy in patients with T3N0 disease has not been previously studied.

Methods

Patients with pathologic T3 CC were identified from a prospective multicenter international trial of ultrastaging in CC. The probability of true nodal negativity (TNN) based on the number of LN examined was calculated for right and left CC. These results were then validated in a cohort of patients with similar inclusion criteria selected from the National Cancer Database (NCDB) between 2006 and 2014.

Results

Three h

SUBMITTER: Dehal AN 

PROVIDER: S-EPMC6776806 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature