A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.

ABSTRACT: Sumoylation is an important post-translational modification that involves the conjugation of the Small Ubiquitin-related Modifier (SUMO) onto target proteins. This modification is reversed through the catalytic activity of SUMO isopeptidases, known as SENPs. One of these SENPs, SENP1, was reported to be overexpressed in human pancreatic cancer cells and patient tissues. Since elevated SENP1 expression levels can be used as a prognostic marker for a subset of cancers, we set out to further explore the overexpression of SENP1 in pancreatic cancer. We found that SENP1 protein levels were not significantly different between pancreatic cancer and normal pancreas-derived cell lines. To evaluate SENP1 expression in patient samples, we analyzed large publicly available datasets and found that SENP

SUBMITTER: Bouchard DM 

PROVIDER: S-EPMC6776818 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature