Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study.

ABSTRACT:

Objective

To determine whether total exposure to penicillin V can be reduced while maintaining adequate clinical efficacy when treating pharyngotonsillitis caused by group A streptococci.

Design

Open label, randomised controlled non-inferiority study.

Setting

17 primary healthcare centres in Sweden between September 2015 and February 2018.

Participants

Patients aged 6 years and over with pharyngotonsillitis caused by group A streptococci and three or four Centor criteria (fever ≥38.5°C, tender lymph nodes, coatings of the tonsils, and absence of cough).

Interventions

Penicillin V 800 mg four times daily for five days (total 16 g) compared with the current recommended dose of 1000 mg three times daily for 10 days (total 30 g).

Main outcome measures

SUBMITTER: Skoog Stahlgren G 

PROVIDER: S-EPMC6776830 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature