Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.

ABSTRACT: Hydrogen sulfide (H₂ S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis. By using xenograft orthotopic implantation of prostate cancer PC3 cells and subsequently comparing bone metastatic with primary tumor-derived cancer cells, we find that H₂ S-producing enzyme cystathionine γ-lyase (CTH) is upregulated in bone-metastatic PC3 cells. Clinical data further reveal that the expression of CTH is elevated in late-stage prostate cancer patients, and higher CTH expression correlates with poor survival from The Cancer Genome Atlas (TCGA) prostate cancer RNA-seq datasets. CTH promotes NF-κB nuclear translocation through H₂ S-

SUBMITTER: Wang YH 

PROVIDER: S-EPMC6776913 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature