Engineering Escherichia coli FAB system using synthetic plant genes for the production of long chain fatty acids.

ABSTRACT:

Background

Sustainable production of microbial fatty acids derivatives has the potential to replace petroleum based equivalents in the chemical, cosmetic and pharmaceutical industry. Most fatty acid sources for production oleochemicals are currently plant derived. However, utilization of these crops are associated with land use change and food competition. Microbial oils could be an alternative source of fatty acids, which circumvents the issue with agricultural competition.

Results

In this study, we generated a chimeric microbial production system that features aspects of both prokaryotic and eukaryotic fatty acid biosynthetic pathways targeted towards the generation of long chain fatty acids. We redirected the type-II fatty acid biosynthetic pathway of Escherichia coli BL2

SUBMITTER: Kassab E 

PROVIDER: S-EPMC6777021 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature