Dataset Information

A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

ABSTRACT: BACKGROUND:Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this article, we conducted a coordinated analysis and summary meta-analysis of new results on the aging-related dynamics linking pulmonary function and cognitive performance. METHODS:We performed coordinated analysis of bivariate growth models in data from 20,586 participants across eight longitudinal studies to examine individual differences in baseline level, rate of change, and occasion-specific variability in pulmonary and cognitive functioning. Results were summarized using meta-analysis. RESULTS:We found consistent but weak baseline and longitudinal associations in levels of pulmonary and cognitive functioning, but no associations in occasion-specific variability. CONCLUSIONS:Results provide limited evidence for a consistent link between simultaneous changes in pulmonary and cognitive function in a normal aging population. Further research is required to understand patterns of onset of decline and differences in rates of change within and across physical and cognitive functioning domains, both within-individuals and across countries and birth cohorts. Coordinated analysis provides an efficient and rigorous approach for replicating and comparing results across independent longitudinal studies.

SUBMITTER: Duggan EC

PROVIDER: S-EPMC6777093 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

Duggan Emily C EC Piccinin Andrea M AM Clouston Sean S Koval Andriy V AV Robitaille Annie A Zammit Andrea R AR Wu Chenkai C Brown Cassandra L CL Lee Lewina O LO Finkel Deborah D Beasley William H WH Kaye Jeffrey J Terrera Graciela Muniz GM Katz Mindy M Lipton Richard B RB Deeg Dorly D Bennett David A DA Praetorius Björk Marcus M Johansson Boo B Spiro Avron A Weuve Jennifer J Hofer Scott M SM

The journals of gerontology. Series A, Biological sciences and medical sciences 20191001 11

<h4>Background</h4>Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this article, we conducted a coordinated analysis and summary meta-a ...[more]

PMID: 30825374

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Project description:IntroductionMaintaining older adults' health and well-being can be achieved through the optimization of physical and mental health, while preserving independence, social participation, and quality of life. Cognitive change has been described as a normal process of aging and it involves domains such as processing speed, attention, memory, language, visuospatial abilities, and executive functioning, among others.ObjectiveTo describe cognitive changes in older adults with healthy aging.MethodsThis is a study that involved data from 14,893 and 14,154 individuals aged >60 years or older from the 2012 and 2015 waves, respectively, who participated in the Mexican Health and Aging Study (MHAS). Participants with healthy aging were identified and described in the MHAS-2012 wave and followed to 2015. Eight cognitive domains evaluated in the Cross-Cultural Cognitive Evaluation (CCCE,) as well as sociodemographic and health characteristics, were described. Criteria for healthy aging involved the following: CCCE ≥ -1.5 standard deviations above the mean on reference norms, independence on basic and instrumental activities of daily living, self-reported "life close to ideal," and preserved functional and social performance.ResultsFrom a total of n = 9,160 older adults from the MHAS-2012 wave, n = 1,080 (11.8%) had healthy aging. In the healthy aging group, the median age was 67 years (IQR: 63-73), 58.1% were female and the median for education was 6 (IQR: 3-8) years. The mean CCCE score was 57 (SD: 16.9) points. In the MHAS-2012 cross-sectional analysis, except for orientation, visuospatial abilities, and verbal fluency, all cognitive domain scores were lower with passing age. When comparing cognitive domain scores in the 225 older adults identified with healthy aging between the 2012 and 2015 MHAS waves, there were almost no observable differences.ConclusionIn the cross-sectional analysis, Mexican adults with healthy aging had lower scores in the verbal learning memory, visual scanning, numeracy, visual memory, and verbal recall domains', as well as lower global cognitive scores in the higher age groups. There were no cognitive changes in the 3 year follow-up, except for a lower gradient of scores in the verbal recall memory domain. Longer prospective studies are needed to characterize greater cognitive changes.

Dataset Information

A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

Publications

A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

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