Association of Antidepressant Use With Adverse Health Outcomes: A Systematic Umbrella Review.

ABSTRACT:

Importance

Antidepressant use is increasing worldwide. Yet, contrasting evidence on the safety of antidepressants is available from meta-analyses, and the credibility of these findings has not been quantified.

Objective

To grade the evidence from published meta-analyses of observational studies that assessed the association between antidepressant use or exposure and adverse health outcomes.

Data sources

PubMed, Scopus, and PsycINFO were searched from database inception to April 5, 2019.

Evidence review

Only meta-analyses of observational studies with a cohort or case-control study design were eligible. Two independent reviewers recorded the data and assessed the methodological quality of the included meta-analyses. Evidence of association was ranked according t

SUBMITTER: Dragioti E 

PROVIDER: S-EPMC6777224 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature