Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis: A Phase 2 Randomized Clinical Trial.

ABSTRACT:

Importance

Atopic dermatitis is associated with substantial patient and caregiver burden. Currently available treatments for atopic dermatitis are inadequate or contraindicated for some patients. Abrocitinib (PF-04965842) is an oral Janus kinase 1 selective inhibitor under investigation for the treatment of atopic dermatitis.

Objective

To investigate the efficacy and safety of abrocitinib for patients with moderate to severe atopic dermatitis.

Design, setting, and participants

A phase 2b, randomized, double-blinded, placebo-controlled, parallel-group trial was conducted from April 15, 2016, to April 4, 2017, at 58 centers in Australia, Canada, Germany, Hungary, and the United States among 267 patients 18 to 75 years of age with a clinical diagnosis of moderate to seve

SUBMITTER: Gooderham MJ 

PROVIDER: S-EPMC6777226 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature