Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment.

ABSTRACT:

Importance

Substantial heterogeneity and uncertainty exist in the observed associations between alcohol consumption and dementia.

Objective

To assess the association between alcohol consumption and dementia and the roles of mild cognitive impairment (MCI) and apolipoprotein E ε4 (APOE E4) genotype in modifying this association.

Design, setting, and participants

This cohort study used data from the Ginkgo Evaluation of Memory Study, conducted from 2000 to 2008 among US community-dwelling participants. This study analyzed 3021 participants aged 72 years and older who were free of dementia. Data analysis was performed from 2017 to 2018.

Exposures

Self-reported alcohol consumption, drinking frequency, and quantity.

Main outcomes and measures

Using multivaria

SUBMITTER: Koch M 

PROVIDER: S-EPMC6777245 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature