Dataset Information

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

ABSTRACT:

Importance

Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.

Objective

To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.

Evidence review

We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.

Findings

In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs).

Conclusions and relevance

The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.

SUBMITTER: Global Burden of Disease Cancer Collaboration

PROVIDER: S-EPMC6777271 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

Fitzmaurice Christina C Abate Degu D Abbasi Naghmeh N Abbastabar Hedayat H Abd-Allah Foad F Abdel-Rahman Omar O Abdelalim Ahmed A Abdoli Amir A Abdollahpour Ibrahim I Abdulle Abdishakur S M ASM Abebe Nebiyu Dereje ND Abraha Haftom Niguse HN Abu-Raddad Laith Jamal LJ Abualhasan Ahmed A Adedeji Isaac Akinkunmi IA Advani Shailesh M SM Afarideh Mohsen M Afshari Mahdi M Aghaali Mohammad M Agius Dominic D Agrawal Sutapa S Ahmadi Ayat A Ahmadian Elham E Ahmadpour Ehsan E Ahmed Muktar Beshir MB Akbari Mohammad Esmaeil ME Akinyemiju Tomi T Al-Aly Ziyad Z AlAbdulKader Assim M AM Alahdab Fares F Alam Tahiya T Alamene Genet Melak GM Alemnew Birhan Tamene T BTT Alene Kefyalew Addis KA Alinia Cyrus C Alipour Vahid V Aljunid Syed Mohamed SM Bakeshei Fatemeh Allah FA Almadi Majid Abdulrahman Hamad MAH Almasi-Hashiani Amir A Alsharif Ubai U Alsowaidi Shirina S Alvis-Guzman Nelson N Amini Erfan E Amini Saeed S Amoako Yaw Ampem YA Anbari Zohreh Z Anber Nahla Hamed NH Andrei Catalina Liliana CL Anjomshoa Mina M Ansari Fereshteh F Ansariadi Ansariadi A Appiah Seth Christopher Yaw SCY Arab-Zozani Morteza M Arabloo Jalal J Arefi Zohreh Z Aremu Olatunde O Areri Habtamu Abera HA Artaman Al A Asayesh Hamid H Asfaw Ephrem Tsegay ET Ashagre Alebachew Fasil AF Assadi Reza R Ataeinia Bahar B Atalay Hagos Tasew HT Ataro Zerihun Z Atique Suleman S Ausloos Marcel M Avila-Burgos Leticia L Avokpaho Euripide F G A EFGA Awasthi Ashish A Awoke Nefsu N Ayala Quintanilla Beatriz Paulina BP Ayanore Martin Amogre MA Ayele Henok Tadesse HT Babaee Ebrahim E Bacha Umar U Badawi Alaa A Bagherzadeh Mojtaba M Bagli Eleni E Balakrishnan Senthilkumar S Balouchi Abbas A Bärnighausen Till Winfried TW Battista Robert J RJ Behzadifar Masoud M Behzadifar Meysam M Bekele Bayu Begashaw BB Belay Yared Belete YB Belayneh Yaschilal Muche YM Berfield Kathleen Kim Sachiko KKS Berhane Adugnaw A Bernabe Eduardo E Beuran Mircea M Bhakta Nickhill N Bhattacharyya Krittika K Biadgo Belete B Bijani Ali A Bin Sayeed Muhammad Shahdaat MS Birungi Charles C Bisignano Catherine C Bitew Helen H Bjørge Tone T Bleyer Archie A Bogale Kassawmar Angaw KA Bojia Hunduma Amensisa HA Borzì Antonio M AM Bosetti Cristina C Bou-Orm Ibrahim R IR Brenner Hermann H Brewer Jerry D JD Briko Andrey Nikolaevich AN Briko Nikolay Ivanovich NI Bustamante-Teixeira Maria Teresa MT Butt Zahid A ZA Carreras Giulia G Carrero Juan J JJ Carvalho Félix F Castro Clara C Castro Franz F Catalá-López Ferrán F Cerin Ester E Chaiah Yazan Y Chanie Wagaye Fentahun WF Chattu Vijay Kumar VK Chaturvedi Pankaj P Chauhan Neelima Singh NS Chehrazi Mohammad M Chiang Peggy Pei-Chia PP Chichiabellu Tesfaye Yitna TY Chido-Amajuoyi Onyema Greg OG Chimed-Ochir Odgerel O Choi Jee-Young J JJ Christopher Devasahayam J DJ Chu Dinh-Toi DT Constantin Maria-Magdalena MM Costa Vera M VM Crocetti Emanuele E Crowe Christopher Stephen CS Curado Maria Paula MP Dahlawi Saad M A SMA Damiani Giovanni G Darwish Amira Hamed AH Daryani Ahmad A das Neves José J Demeke Feleke Mekonnen FM Demis Asmamaw Bizuneh AB Demissie Birhanu Wondimeneh BW Demoz Gebre Teklemariam GT Denova-Gutiérrez Edgar E Derakhshani Afshin A Deribe Kalkidan Solomon KS Desai Rupak R Desalegn Beruk Berhanu BB Desta Melaku M Dey Subhojit S Dharmaratne Samath Dhamminda SD Dhimal Meghnath M Diaz Daniel D Dinberu Mesfin Tadese Tadese MTT Djalalinia Shirin S Doku David Teye DT Drake Thomas M TM Dubey Manisha M Dubljanin Eleonora E Duken Eyasu Ejeta EE Ebrahimi Hedyeh H Effiong Andem A Eftekhari Aziz A El Sayed Iman I Zaki Maysaa El Sayed MES El-Jaafary Shaimaa I SI El-Khatib Ziad Z Elemineh Demelash Abewa DA Elkout Hajer H Ellenbogen Richard G RG Elsharkawy Aisha A Emamian Mohammad Hassan MH Endalew Daniel Adane DA Endries Aman Yesuf AY Eshrati Babak B Fadhil Ibtihal I Fallah Omrani Vahid V Faramarzi Mahbobeh M Farhangi Mahdieh Abbasalizad MA Farioli Andrea A Farzadfar Farshad F Fentahun Netsanet N Fernandes Eduarda E Feyissa Garumma Tolu GT Filip Irina I Fischer Florian F Fisher James L JL Force Lisa M LM Foroutan Masoud M Freitas Marisa M Fukumoto Takeshi T Futran Neal D ND Gallus Silvano S Gankpe Fortune Gbetoho FG Gayesa Reta Tsegaye RT Gebrehiwot Tsegaye Tewelde TT Gebremeskel Gebreamlak Gebremedhn GG Gebremeskel Gebreamlak Gebremedhn GG Gedefaw Getnet Azeze GA Gelaw Belayneh K BK Geta Birhanu B Getachew Sefonias S Gezae Kebede Embaye KE Ghafourifard Mansour M Ghajar Alireza A Ghashghaee Ahmad A Gholamian Asadollah A Gill Paramjit Singh PS Ginindza Themba T G TTG Girmay Alem A Gizaw Muluken M Gomez Ricardo Santiago RS Gopalani Sameer Vali SV Gorini Giuseppe G Goulart Bárbara Niegia Garcia BNG Grada Ayman A Ribeiro Guerra Maximiliano M Guimaraes Andre Luiz Sena ALS Gupta Prakash C PC Gupta Rahul R Hadkhale Kishor K Haj-Mirzaian Arvin A Haj-Mirzaian Arya A Hamadeh Randah R RR Hamidi Samer S Hanfore Lolemo Kelbiso LK Haro Josep Maria JM Hasankhani Milad M Hasanzadeh Amir A Hassen Hamid Yimam HY Hay Roderick J RJ Hay Simon I SI Henok Andualem A Henry Nathaniel J NJ Herteliu Claudiu C Hidru Hagos D HD Hoang Chi Linh CL Hole Michael K MK Hoogar Praveen P Horita Nobuyuki N Hosgood H Dean HD Hosseini Mostafa M Hosseinzadeh Mehdi M Hostiuc Mihaela M Hostiuc Sorin S Househ Mowafa M Hussen Mohammedaman Mama MM Ileanu Bogdan B Ilic Milena D MD Innos Kaire K Irvani Seyed Sina Naghibi SSN Iseh Kufre Robert KR Islam Sheikh Mohammed Shariful SMS Islami Farhad F Jafari Balalami Nader N Jafarinia Morteza M Jahangiry Leila L Jahani Mohammad Ali MA Jahanmehr Nader N Jakovljevic Mihajlo M James Spencer L SL Javanbakht Mehdi M Jayaraman Sudha S Jee Sun Ha SH Jenabi Ensiyeh E Jha Ravi Prakash RP Jonas Jost B JB Jonnagaddala Jitendra J Joo Tamas T Jungari Suresh Banayya SB Jürisson Mikk M Kabir Ali A Kamangar Farin F Karch André A Karimi Narges N Karimian Ansar A Kasaeian Amir A Kasahun Gebremicheal Gebreslassie GG Kassa Belete B Kassa Tesfaye Dessale TD Kassaw Mesfin Wudu MW Kaul Anil A Keiyoro Peter Njenga PN Kelbore Abraham Getachew AG Kerbo Amene Abebe AA Khader Yousef Saleh YS Khalilarjmandi Maryam M Khan Ejaz Ahmad EA Khan Gulfaraz G Khang Young-Ho YH Khatab Khaled K Khater Amir A Khayamzadeh Maryam M Khazaee-Pool Maryam M Khazaei Salman S Khoja Abdullah T AT Khosravi Mohammad Hossein MH Khubchandani Jagdish J Kianipour Neda N Kim Daniel D Kim Yun Jin YJ Kisa Adnan A Kisa Sezer S Kissimova-Skarbek Katarzyna K Komaki Hamidreza H Koyanagi Ai A Krohn Kristopher J KJ Bicer Burcu Kucuk BK Kugbey Nuworza N Kumar Vivek V Kuupiel Desmond D La Vecchia Carlo C Lad Deepesh P DP Lake Eyasu Alem EA Lakew Ayenew Molla AM Lal Dharmesh Kumar DK Lami Faris Hasan FH Lan Qing Q Lasrado Savita S Lauriola Paolo P Lazarus Jeffrey V JV Leigh James J Leshargie Cheru Tesema CT Liao Yu Y Limenih Miteku Andualem MA Listl Stefan S Lopez Alan D AD Lopukhov Platon D PD Lunevicius Raimundas R Madadin Mohammed M Magdeldin Sameh S El Razek Hassan Magdy Abd HMA Majeed Azeem A Maleki Afshin A Malekzadeh Reza R Manafi Ali A Manafi Navid N Manamo Wondimu Ayele WA Mansourian Morteza M Mansournia Mohammad Ali MA Mantovani Lorenzo Giovanni LG Maroufizadeh Saman S Martini Santi Martini S SMS Mashamba-Thompson Tivani Phosa TP Massenburg Benjamin Ballard BB Maswabi Motswadi Titus MT Mathur Manu Raj MR McAlinden Colm C McKee Martin M Meheretu Hailemariam Abiy Alemu HAA Mehrotra Ravi R Mehta Varshil V Meier Toni T Melaku Yohannes A YA Meles Gebrekiros Gebremichael GG Meles Hagazi Gebre HG Melese Addisu A Melku Mulugeta M Memiah Peter T N PTN Mendoza Walter W Menezes Ritesh G RG Merat Shahin S Meretoja Tuomo J TJ Mestrovic Tomislav T Miazgowski Bartosz B Miazgowski Tomasz T Mihretie Kebadnew Mulatu M KMM Miller Ted R TR Mills Edward J EJ Mir Seyed Mostafa SM Mirzaei Hamed H Mirzaei Hamid Reza HR Mishra Rashmi R Moazen Babak B Mohammad Dara K DK Mohammad Karzan Abdulmuhsin KA Mohammad Yousef Y Darwesh Aso Mohammad AM Mohammadbeigi Abolfazl A Mohammadi Hiwa H Mohammadi Moslem M Mohammadian Mahdi M Mohammadian-Hafshejani Abdollah A Mohammadoo-Khorasani Milad M Mohammadpourhodki Reza R Mohammed Ammas Siraj AS Mohammed Jemal Abdu JA Mohammed Shafiu S Mohebi Farnam F Mokdad Ali H AH Monasta Lorenzo L Moodley Yoshan Y Moosazadeh Mahmood M Moossavi Maryam M Moradi Ghobad G Moradi-Joo Mohammad M Moradi-Lakeh Maziar M Moradpour Farhad F Morawska Lidia L Morgado-da-Costa Joana J Morisaki Naho N Morrison Shane Douglas SD Mosapour Abbas A Mousavi Seyyed Meysam SM Muche Achenef Asmamaw AA Muhammed Oumer Sada S OSS Musa Jonah J Nabhan Ashraf F AF Naderi Mehdi M Nagarajan Ahamarshan Jayaraman AJ Nagel Gabriele G Nahvijou Azin A Naik Gurudatta G Najafi Farid F Naldi Luigi L Nam Hae Sung HS Nasiri Naser N Nazari Javad J Negoi Ionut I Neupane Subas S Newcomb Polly A PA Nggada Haruna Asura HA Ngunjiri Josephine W JW Nguyen Cuong Tat CT Nikniaz Leila L Ningrum Dina Nur Anggraini DNA Nirayo Yirga Legesse YL Nixon Molly R MR Nnaji Chukwudi A CA Nojomi Marzieh M Nosratnejad Shirin S Shiadeh Malihe Nourollahpour MN Obsa Mohammed Suleiman MS Ofori-Asenso Richard R Ogbo Felix Akpojene FA Oh In-Hwan IH Olagunju Andrew T AT Olagunju Tinuke O TO Oluwasanu Mojisola Morenike MM Omonisi Abidemi E AE Onwujekwe Obinna E OE Oommen Anu Mary AM Oren Eyal E Ortega-Altamirano Doris D V DDV Ota Erika E Otstavnov Stanislav S SS Owolabi Mayowa Ojo MO P A Mahesh M Padubidri Jagadish Rao JR Pakhale Smita S Pakpour Amir H AH Pana Adrian A Park Eun-Kee EK Parsian Hadi H Pashaei Tahereh T Patel Shanti S Patil Snehal T ST Pennini Alyssa A Pereira David M DM Piccinelli Cristiano C Pillay Julian David JD Pirestani Majid M Pishgar Farhad F Postma Maarten J MJ Pourjafar Hadi H Pourmalek Farshad F Pourshams Akram A Prakash Swayam S Prasad Narayan N Qorbani Mostafa M Rabiee Mohammad M Rabiee Navid N Radfar Amir A Rafiei Alireza A Rahim Fakher F Rahimi Mahdi M Rahman Muhammad Aziz MA Rajati Fatemeh F Rana Saleem M SM Raoofi Samira S Rath Goura Kishor GK Rawaf David Laith DL Rawaf Salman S Reiner Robert C RC Renzaho Andre M N AMN Rezaei Nima N Rezapour Aziz A Ribeiro Ana Isabel AI Ribeiro Daniela D Ronfani Luca L Roro Elias Merdassa EM Roshandel Gholamreza G Rostami Ali A Saad Ragy Safwat RS Sabbagh Parisa P Sabour Siamak S Saddik Basema B Safiri Saeid S Sahebkar Amirhossein A Salahshoor Mohammad Reza MR Salehi Farkhonde F Salem Hosni H Salem Marwa Rashad MR Salimzadeh Hamideh H Salomon Joshua A JA Samy Abdallah M AM Sanabria Juan J Santric Milicevic Milena M MM Sartorius Benn B Sarveazad Arash A Sathian Brijesh B Satpathy Maheswar M Savic Miloje M Sawhney Monika M Sayyah Mehdi M Schneider Ione J C IJC Schöttker Ben B Sekerija Mario M Sepanlou Sadaf G SG Sepehrimanesh Masood M Seyedmousavi Seyedmojtaba S Shaahmadi Faramarz F Shabaninejad Hosein H Shahbaz Mohammad M Shaikh Masood Ali MA Shamshirian Amir A Shamsizadeh Morteza M Sharafi Heidar H Sharafi Zeinab Z Sharif Mehdi M Sharifi Ali A Sharifi Hamid H Sharma Rajesh R Sheikh Aziz A Shirkoohi Reza R Shukla Sharvari Rahul SR Si Si S Siabani Soraya S Silva Diego Augusto Santos DAS Silveira Dayane Gabriele Alves DGA Singh Ambrish A Singh Jasvinder A JA Sisay Solomon S Sitas Freddy F Sobngwi Eugène E Soofi Moslem M Soriano Joan B JB Stathopoulou Vasiliki V Sufiyan Mu'awiyyah Babale MB Tabarés-Seisdedos Rafael R Tabuchi Takahiro T Takahashi Ken K Tamtaji Omid Reza OR Tarawneh Mohammed Rasoul MR Tassew Segen Gebremeskel SG Taymoori Parvaneh P Tehrani-Banihashemi Arash A Temsah Mohamad-Hani MH Temsah Omar O Tesfay Berhe Etsay BE Tesfay Fisaha Haile FH Teshale Manaye Yihune MY Tessema Gizachew Assefa GA Thapa Subash S Tlaye Kenean Getaneh KG Topor-Madry Roman R Tovani-Palone Marcos Roberto MR Traini Eugenio E Tran Bach Xuan BX Tran Khanh Bao KB Tsadik Afewerki Gebremeskel AG Ullah Irfan I Uthman Olalekan A OA Vacante Marco M Vaezi Maryam M Varona Pérez Patricia P Veisani Yousef Y Vidale Simone S Violante Francesco S FS Vlassov Vasily V Vollset Stein Emil SE Vos Theo T Vosoughi Kia K Vu Giang Thu GT Vujcic Isidora S IS Wabinga Henry H Wachamo Tesfahun Mulatu TM Wagnew Fasil Shiferaw FS Waheed Yasir Y Weldegebreal Fitsum F Weldesamuel Girmay Teklay GT Wijeratne Tissa T Wondafrash Dawit Zewdu DZ Wonde Tewodros Eshete TE Wondmieneh Adam Belay AB Workie Hailemariam Mekonnen HM Yadav Rajaram R Yadegar Abbas A Yadollahpour Ali A Yaseri Mehdi M Yazdi-Feyzabadi Vahid V Yeshaneh Alex A Yimam Mohammed Ahmed MA Yimer Ebrahim M EM Yisma Engida E Yonemoto Naohiro N Younis Mustafa Z MZ Yousefi Bahman B Yousefifard Mahmoud M Yu Chuanhua C Zabeh Erfan E Zadnik Vesna V Moghadam Telma Zahirian TZ Zaidi Zoubida Z Zamani Mohammad M Zandian Hamed H Zangeneh Alireza A Zaki Leila L Zendehdel Kazem K Zenebe Zerihun Menlkalew ZM Zewale Taye Abuhay TA Ziapour Arash A Zodpey Sanjay S Murray Christopher J L CJL

JAMA oncology 20191201 12

<h4>Importance</h4>Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in ac ...[more]

PMID: 31560378

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Project description:BackgroundThe Chinese population has aged significantly in the last few decades. Comprehensive health losses including both fatal and non-fatal health outcomes associated with ageing in China have not been detailed.MethodsBased on freely accessible disability adjusted life years (DALYs) estimated by the Global Burden of Diseases (GBD) 2017, we adopted a robust decomposition method that ascribes changes in DALYs in any given country across two time points to changes resulting from three sources: population size, age structure, and age-specific DALYs rate per 100,000 population. Using the method, we calculated DALYs associated with population ageing in China from 1990 to 2017 and examined the counteraction between the effects of DALYs rate change and population ageing. This method extends previous work through attributing the change in DALYs to the three sources.ResultsPopulation ageing was associated with 92.8 million DALYs between 1990 and 2017 in China, of which 65.8% (61.1 million) were years of life lost (YLLs). Males had comparatively more DALYs associated with population ageing than females in the study period. The five leading causes of DALYs associated with population ageing between 1990 and 2017 were stroke (23.6 million), chronic obstructive pulmonary disease (COPD) (18.3 million), ischemic heart disease (13.0 million), tracheal, bronchus, and lung cancer (6.1 million) and liver cancer (5.0 million). Between 1990 and 2017, changes in DALYs associated with age-specific DALY rate reductions far exceeded those related to population ageing (- 196.2 million versus 92.8 million); 57.5% (- 112.8 million) of DALYs were caused by decreases in rates attributed to 84 modifiable risk factors.ConclusionPopulation ageing was associated with growing health loss in China from 1990 to 2017. Despite the recent progress in alleviating health loss associated with population ageing, the government should encourage scientific research on effective and affordable prevention and control strategies and should consider investment in resources to implement strategies nationwide to address the future challenge of population ageing.

Project description:BackgroundTo understand the magnitude and spatial-temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) in Guangdong, China.MethodsWe undertook a longitudinal study based on a multicenter database established by the Health Commission of Guangdong, involving a total of 21 prefectures and four economic regions in the Guangdong province. A total of 520,731 medical records from patients with severe mental disorders were collected for 2010-2020. Data were analyzed via an integrated evaluation framework by synthesizing prevalence estimates, epidemiological adjustment as well as comorbidity assessment to develop internally consistent estimates of DALY. DALY changes during 2010-2020 were decomposed by population growth and aging and further grouped by Socio-demographic Index (SDI). DALYs were projected to 2030 by the weighted median annualized rate of change in 2010-2020.ResultsIn 2010-2020, the average DALYs for severe mental disorders reached 798,474 (95% uncertainty interval [UI]: 536,280-1,270,465) person-years (52.2% for males, and 47.8% for females). Severe mental disorders led to a great amount of disease burden, especially in Guangzhou, Shenzhen, and Foshan cities. Schizophrenia and mental retardation with mental disorders were the two leading sources of the burden ascribed to severe mental disorders. Population growth and aging could be accountable for the increasing burden of severe mental disorders. Economic regions with higher SDI carried a greater burden but had lower annualized rates of change in DALYs. The overall burden of severe mental disorders is projected to rise modestly over the next decade.ConclusionsThe findings urge prioritization of initiatives focused on public mental health, prevention strategies, health resources reallocation, and active involvement of authorities to effectively address the anticipated needs.

Project description:AimEating disorders have increasingly become a public health concern globally. This study aimed to reveal the burden of eating disorders at the global, regional and national levels using the Global Burden of Disease (GBD) Study 2017 data.MethodsWe extracted the age-standardised rates (ASRs) of prevalence and disability-adjusted life years (DALYs) and their 95% uncertainty intervals (UIs) of eating disorders, including anorexia nervosa and bulimia nervosa, between 1990 and 2017 from the GBD 2017 data. The estimated annual percentage changes (EAPCs) were calculated to quantify the secular trends of the burden of eating disorders.ResultsThe ASRs of prevalence and the DALYs of eating disorders continuously increased worldwide from 1990 to 2017 by an average of 0.65 (95% UI: 0.59-0.71) and 0.66 (95% UI: 0.60-0.72), respectively. The burden of eating disorders was higher in females than in males, but the increment in ASRs was greater in males than in females over time. In 2017, the highest burden of eating disorders was observed in the high sociodemographic index (SDI) regions, especially Australasia (ASR of prevalence = 807.13, 95% UI: 664.20-982.30; ASR of DALYs = 170.74, 95% UI: 113.43-244.14, per 100 000 population), Western Europe and high-income North America. However, the most significant increment of the burden of eating disorders was observed in East Asia (EAPC for prevalence = 2.23, 95% UI: 2.14-2.32; EAPC for DALYs = 2.22, 95% UI: 2.13-2.31), followed by South Asia. An increasing trend in the burden of eating disorders at the national level was observed among most countries or territories. The countries with the top three highest increasing trends were Equatorial Guinea, Bosnia and Herzegovina and China. Positive associations were found between the burden estimates and the SDI levels in almost all geographic regions during the observed 28-year period. We also found that the human development indexes in 2017 were positively correlated with the EAPCs of the ASRs of prevalence (ρ = 0.222, P = 0.002) and DALYs (ρ = 0.208, P = 0.003).ConclusionThe highest burden of eating disorders remains in the high-income western countries, but an increasing trend was observed globally and in all SDI-quintiles, especially in Asian regions that were highly populous. These results could help governments worldwide formulate suitable medical and health policies for the prevention and early intervention of eating disorders.

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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

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