Ontology highlight
ABSTRACT:
SUBMITTER: Takao D
PROVIDER: S-EPMC6777370 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Takao Daisuke D Watanabe Koki K Kuroki Kanako K Kitagawa Daiju D
Biology open 20190918 9
Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged proteins in human cells throughout the entire cell cycle, we quantitatively tracked the dynamics of the critical duplication factors: Plk4, STIL and HsSAS6. Centriolar Plk4 peaks and then starts decreasing during the late G1 phase, which coincid ...[more]