Common Secondary Genomic Variants Associated With Advanced Epithelioid Hemangioendothelioma.

ABSTRACT:

Importance

Epithelioid hemangioendothelioma (EHE) is a rare, malignant vascular sarcoma characterized in most cases by a WWTR1-CAMTA1 fusion. The clinical course of EHE exhibits a dual nature. The condition is often indolent but can rapidly grow and metastasize unpredictably. No biomarkers to date are available to predict this phenotype. The hypothesis of this study was that better defining the genomic landscape of EHE using next-generation sequencing could offer additional therapies and insight into clinical outcomes.

Objective

To characterize secondary EHE genomic alterations and their association with clinical outcomes.

Design, setting, and participants

Multicenter, cross-sectional, retrospective study of next-generation sequencing results collected from participan

SUBMITTER: Seligson ND 

PROVIDER: S-EPMC6777396 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature