Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals.

ABSTRACT: Some of the most widely studied variants in psychiatric genetics include variable number tandem repeat variants (VNTRs) in SLC6A3, DRD4, SLC6A4, and MAOA. While initial findings suggested large effects, their importance with respect to psychiatric phenotypes is the subject of much debate with broadly conflicting results. Despite broad interest, these loci remain absent from the largest available samples, such as the UK Biobank, limiting researchers' ability to test these contentious hypotheses rigorously in large samples. Here, using two independent reference datasets, we report out-of-sample imputation accuracy estimates of >0.96 for all four VNTR variants and one modifying SNP, depending on the reference and target dataset. We describe the imputation procedures of these candidate variant

SUBMITTER: Border R 

PROVIDER: S-EPMC6777532 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature