Risk factors for the development of idiopathic pulmonary fibrosis: A review.

ABSTRACT:

Purpose of review

Idiopathic pulmonary fibrosis (IPF) is an invariably progressive disease. Current treatment options simply slow disease progression and better therapeutic options are needed. We aimed to review emerging literature on risk factors associated with the development of IPF.

Recent findings

There is increasing data to support the role of intrinsic risk factors (e.g. genetics, aging, sex, lung microbiome), co-morbidities (e.g. gastroesophageal reflux, obstructive sleep apnea, diabetes mellitus, herpes virus infection), and extrinsic risk factors (e.g. cigarette smoking, environmental exposures, air pollution) in IPF development. These risk factors may independently increase susceptibility for IPF or act in a synergistic fashion to contribute to increased risk for

SUBMITTER: Zaman T 

PROVIDER: S-EPMC6777743 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature