Decrements of body mass index are associated with poor outcomes of idiopathic pulmonary fibrosis patients.

ABSTRACT:

Background

The processes that result in progression of idiopathic pulmonary fibrosis (IPF) remain enigmatic. Moreover, the course of this disease can be highly variable and difficult to accurately predict. We hypothesized analyses of body mass index (BMI), a simple, routine clinical measure, may also have prognostic value in these patients, and might provide mechanistic insights. We investigated the associations of BMI changes with outcome, plasma adipokines, and adaptive immune activation among IPF patients.

Methods

Data were analyzed in an IPF discovery cohort (n = 131) from the University of Pittsburgh, and findings confirmed in patients from the University of Alabama at Birmingham (n = 148). Plasma adipokines were measured by ELISA and T-cell phenotypes determined by flo

SUBMITTER: Kulkarni T 

PROVIDER: S-EPMC6777779 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature