A distinct glycerophospholipid metabolism signature of acute graft versus host disease with predictive value.

ABSTRACT:

Background

Acute graft-versus-host disease (aGvHD) is a major factor that limits the successful outcomes of allogeneic hematopoietic cell transplantation (alloHSCT). Currently there are few validated biomarkers that can help predict the risk of aGvHD in clinical settings.

Methods

We performed an integrated metabolomics and transcriptomics study and identified biomarkers that distinguish alloHSCT recipients with aGvHD from alloHSCT recipients without aGvHD in two separate cohorts.

Results

Pathway analysis of 38 significantly altered metabolites and 1148 differentially expressed genes uncovered a distinctly altered glycerophospholipid (GPL) metabolism network. Subsequently, we developed an aGvHD risk score (GRS) based on 5 metabolites markers from GPL metabolism to pred

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6777804 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature