Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for improved understanding of the biology of PDA progression, a highly complex and dynamic process featuring changes in cancer cells and stromal cells. A comprehensive characterization of PDA cancer cell and stromal cell heterogeneity during disease progression is lacking. In this study, we aimed to profile cell populations and understand their phenotypic changes during PDA progression. To that end, we employed single-cell RNA sequencing technology to agnostically profile cell heterogeneity during different stages of PDA progression in genetically engineered mouse models. Our data indicate that an epithelial-to-mesenchymal transition of cancer

SUBMITTER: Hosein AN 

PROVIDER: S-EPMC6777805 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature