Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects.

ABSTRACT: Targeting the dynamic tumor immune microenvironment (TIME) can provide effective therapeutic strategies for cancer. Neutrophils are the predominant leukocyte population in mice and humans, and mounting evidence implicates these cells during tumor growth and metastasis. Neutrophil extracellular traps (NETs) are networks of extracellular neutrophil DNA fibers that are capable of binding tumor cells to support metastatic progression. Here we demonstrate for the first time that circulating NET levels are elevated in advanced esophageal, gastric and lung cancer patients compared to healthy controls. Using pre-clinical murine models of lung and colon cancer in combination with intravital video microscopy, we show that NETs functionally regulate disease progression and that blocking NETosis throu

SUBMITTER: Rayes RF 

PROVIDER: S-EPMC6777835 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature