Network remodeling induced by transcranial brain stimulation: A computational model of tDCS-triggered cell assembly formation.

ABSTRACT: Transcranial direct current stimulation (tDCS) is a variant of noninvasive neuromodulation, which promises treatment for brain diseases like major depressive disorder. In experiments, long-lasting aftereffects were observed, suggesting that persistent plastic changes are induced. The mechanism underlying the emergence of lasting aftereffects, however, remains elusive. Here we propose a model, which assumes that tDCS triggers a homeostatic response of the network involving growth and decay of synapses. The cortical tissue exposed to tDCS is conceived as a recurrent network of excitatory and inhibitory neurons, with synapses subject to homeostatically regulated structural plasticity. We systematically tested various aspects of stimulation, including electrode size and montage, as well as sti

SUBMITTER: Lu H 

PROVIDER: S-EPMC6777963 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature