Synthesis of the EFG Framework of Tamulamides A and B.

ABSTRACT: Synthesis of the fused polycyclic ether motif comprising the EFG rings of the marine ladder polyethers tamulamides A and B has been achieved via two different etherification strategies. Ultimately, a reductive etherification approach proved most successful due to tolerance of the G ring substitution and provided the EFG 6,7,6 ring system in 58% yield.

SUBMITTER: Kelley EH 

PROVIDER: S-EPMC6778004 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature