Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP.

ABSTRACT:

Objectives

This study investigated the differential regulation of circulating atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with acute decompensated heart failure (ADHF) and tested the hypothesis that a relative deficiency of ANP exists in a subgroup of patients with ADHF.

Background

The endocrine heart releases the cardiac hormones ANP and BNP, which play a key role in cardiovascular (CV), renal, and metabolic homeostasis. In heart failure (HF), both plasma ANP and BNP are increased as a compensatory homeostatic response to myocardial overload.

Methods

ANP and BNP concentrations were measured in a small group of patients with ADHF (n = 112). To support this study's goal, a total of 129 healthy subjects were prospectively recruited

SUBMITTER: Reginauld SH 

PROVIDER: S-EPMC6778016 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature