Remotely controlled chemomagnetic modulation of targeted neural circuits.

ABSTRACT: Connecting neural circuit output to behaviour can be facilitated by the precise chemical manipulation of specific cell populations^1,2. Engineered receptors exclusively activated by designer small molecules enable manipulation of specific neural pathways^3,4. However, their application to studies of behaviour has thus far been hampered by a trade-off between the low temporal resolution of systemic injection versus the invasiveness of implanted cannulae or infusion pumps². Here, we developed a remotely controlled chemomagnetic modulation-a nanomaterials-based technique that permits the pharmacological interrogation of targeted neural populations in freely moving subjects. The heat dissipated by magnetic nanoparticles (MNPs) in the presence of alternating magne

SUBMITTER: Rao S 

PROVIDER: S-EPMC6778020 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature