Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

ABSTRACT: Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. Here, we developed human cortical organoids that dynamically change cellular populations during maturation and exhibited consistent increases in electrical activity over the span of several months. The spontaneous network formation displayed periodic and regular oscillatory events that were dependent on glutamatergic and GABAergic signaling. The oscillatory activity transitioned to more spatiotemporally irregular patterns, and synchronous network events resembled features similar to those observ

SUBMITTER: Trujillo CA 

PROVIDER: S-EPMC6778040 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature