Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis.

ABSTRACT: Maintaining protein homeostasis is an essential requirement for cell and organismal viability. An elaborate regulatory system within cells, the protein homeostasis network, safeguards that proteins are correctly folded and functional. At the heart of this regulatory system lies a class of specialized protein quality control enzymes called chaperones that are tasked with assisting proteins in their folding, avoiding aggregation and degradation. Failure and decline of protein homeostasis are directly associated with conditions of aging and aging-related neurodegeneration. However, it is not clear what tips the balance of protein homeostasis and leads to onset of aging and diseases. Here, using a comparative genomics approach we report general principles of maintaining protein homeostasis acr

SUBMITTER: Draceni Y 

PROVIDER: S-EPMC6778244 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature