Identifying roles for peptidergic signaling in mice.

ABSTRACT: Despite accumulating evidence demonstrating the essential roles played by neuropeptides, it has proven challenging to use this information to develop therapeutic strategies. Peptidergic signaling can involve juxtacrine, paracrine, endocrine, and neuronal signaling, making it difficult to define physiologically important pathways. One of the final steps in the biosynthesis of many neuropeptides requires a single enzyme, peptidylglycine α-amidating monooxygenase (PAM), and lack of amidation renders most of these peptides biologically inert. PAM, an ancient integral membrane enzyme that traverses the biosynthetic and endocytic pathways, also affects cytoskeletal organization and gene expression. While mice, zebrafish, and flies lacking Pam (Pam^KO/KO ) are not viable,

SUBMITTER: Powers KG 

PROVIDER: S-EPMC6778246 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature