Structural basis of molecular logic OR in a dual-sensor histidine kinase.

ABSTRACT: Signal detection and integration by sensory proteins constitute the critical molecular events as living organisms respond to changes in a complex environment. Many sensory proteins adopt a modular architecture that integrates the perception of distinct chemical or physical signals and the generation of a biological response in the same protein molecule. Currently, how signal perception and integration are achieved in such a modular, often dimeric, framework remains elusive. Here, we report a dynamic crystallography study on the tandem sensor domains of a dual-sensor histidine kinase PPHK (phosphorylation-responsive photosensitive histidine kinase) that operates a molecular logic OR, by which the output kinase activity is modulated by a phosphorylation signal and a light signal. A joint ana

SUBMITTER: Shin H 

PROVIDER: S-EPMC6778262 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature