Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures.

ABSTRACT:

Background and aim

Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with decreases in blood pressure and CVD risk. Our aim was to investigate the association between endogenous GLP-1 responses to oral glucose and peripheral and central haemodynamic measures in a population at risk of diabetes and CVD.

Methods

This cross-sectional study included 837 Danish individuals from the ADDITION-PRO cohort (52% men, median (interquartile range) age 65.5 (59.8 to 70.7) years, BMI 26.1 (23.4 to 28.5) kg/m², without antihypertensive treatment and known diabetes). All participants received an oral glucose tolerance test with me

SUBMITTER: Lundgren JR 

PROVIDER: S-EPMC6778378 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature