Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults.

ABSTRACT:

Objective

Public health recommendations promote social engagement to reduce risk of cognitive decline and dementia. The objective of this study was to evaluate the longitudinal associations of social engagement and cognition in cognitively normal older adults with varying levels of neocortical amyloid-β, the Alzheimer's disease (AD) pathologic marker.

Methods

Two hundred seventeen men and women, age 63-89 underwent assessments for social engagement and cognitive performance at baseline and 3 years later using the Community Healthy Activities Model Program for Seniors questionnaire and the Preclinical Alzheimer Cognitive Composite (PACC). Amyloid-β was measured using Pittsburgh compound B-PET. Multivariable regression models estimated main and interactive effects of baseline

SUBMITTER: Biddle KD 

PROVIDER: S-EPMC6778491 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature