Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia.

ABSTRACT:

Objectives

To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes.

Methods

This was a single institution ancillary study to a prospective observational study (N = 20 consecutive adults aged ≥60 with newly diagnosed AML who received induction chemotherapy). Biomarkers (Interleukin-6 [IL-6], IL-6 soluble receptor [IL-6 sR], tumor necrosis factor alpha [TNFα], TNFα soluble receptor 1 [TNFα sR1], interleukin-3 [IL-3], C-reactive protein [CRP]) were collected at start of induction, weekly for three weeks, and post-induction and were compared over time using paired t-tests. GA was administered at baseline and post-induction, and correla

SUBMITTER: Loh KP 

PROVIDER: S-EPMC6778500 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature