Mapping the landscape of human dopamine D2/3 receptors with [¹¹C]raclopride.

ABSTRACT: The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BP_ND in the extrastriatal regions with [¹¹C]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [¹¹C]raclopride across the human brain in a large sample (N = 176; age range 64-68 years). Structural equation modeling revealed that D2/3DR availability can be organized acc

SUBMITTER: Papenberg G 

PROVIDER: S-EPMC6778542 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature