Metabolomics: a search for biomarkers of visceral fat and liver fat content.

ABSTRACT:

Intoduction

Excess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations such as waist circumference.

Objective

We explored the potential use of plasma metabolites as biomarkers of visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC).

Methods

We performed a cross-sectional analysis of a subset of the Netherlands Epidemiology of Obesity study. Plasma metabolite profiles were determined using the Biocrates AbsoluteIDQ p150 kit in 176 individuals with normal fasting plasma glucose. VAT was assessed with magnetic resonance imaging and HTGC with proton-MR spectroscopy. We used linear

SUBMITTER: Boone S 

PROVIDER: S-EPMC6778586 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature