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Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

ABSTRACT: AIM:The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus (DM). BACKGROUND:Modern SUs may be considered a panacea in DM care with their beneficial extra-pancreatic, pleiotropic, and cardiovascular effects. Safe glycemic control with SUs could be achieved with appropriate patient selection, drug and dosage selection, and patient empowerment. Additionally, sulfonylureas also exhibit certain endocrine and metabolic effects, which could be considered beneficial in the management of DM. In this regard, a group of international clinical experts discussed the less known beneficial aspects of SUs and safe and smart prescription of modern SUs in DM care. RESULTS:The concept of glucocrinology or the relationship of glycemia with the endocrine system was emphasized during the meetings. Clinical experts arrived at a consensus for the usage of modern SUs in the presence of other endocrine dysfunction and the impact of these drugs on endocrine health. The beneficial pleiotropic and cardiovascular effects of modern SUs were also discussed. The key discussion points were considered to develop clinical expert opinions for the use of modern SUs in persons with DM. Clinical expert opinions were developed for indications, pleiotropic benefits, cardiovascular outcomes, adherence, and safe use of modern SUs. CONCLUSIONS:Appropriate clinical judgement coupled with a patient-centered approach is crucial to achieve the best outcome in persons with DM. Owing to their safety, efficacy, extra-pancreatic benefits including effects on endocrine and metabolic aspects, and low cost of therapy, modern SUs could be considered as drugs/agents of choice for the treatment of diabetes. FUNDING:Sanofi India.

SUBMITTER: Kalra S

PROVIDER: S-EPMC6778594 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

Kalra Sanjay S Das A K AK Baruah M P MP Unnikrishnan A G AG Dasgupta Arundhati A Shah Parag P Sahay Rakesh R Shukla Rishi R Das Sambit S Tiwaskar Mangesh M Vijayakumar G G Chawla Manoj M Eliana Fatimah F Suastika Ketut K Orabi Abbas A Rahim Aly Ahmed Abdul AAA Uloko Andrew A Bahendeka Silver S Abdela Abdurezak Ahmed AA Mohammed Fariduddin F Pathan Faruque F Rahman Muhammed Hafizur MH Afsana Faria F Selim Shajada S Moosa Muaz M Murad Moosa M Shreshtha Pradeep Krishna PK Shreshtha Dina D Giri Mimi M Hussain Wiam W Al-Ani Ahmed A Ramaiya Kaushik K Singh Surender S Raza Syed Abbas SA Aye Than Than TT Garusinghe Chaminda C Muthukuda Dimuthu D Weerakkody Muditha M Kahandawa Shyaminda S Bavuma Charlotte C Ruder Sundeep S Vanny Koy K Khanolkar Manish M Czupryniak Leszek L

Diabetes therapy : research, treatment and education of diabetes and related disorders 20190702 5

<h4>Aim</h4>The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus (DM).<h4>Background</h4>Modern SUs may be considered a panacea in DM care with their beneficial extra-pancreatic, pleiotropic, and cardiovascular effects. Safe glycemic control with SUs could be achieved with appropriate patient selection, dr ...[more]

PMID: 31267358

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Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

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Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

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