Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.

ABSTRACT: Patient-derived xenograft (PDX) models are a useful tool in cancer biology research. However, the number of lung cancer PDX is limited. In the present study, we successfully established 10 PDX, including three adenocarcinoma (AD), six squamous cell carcinoma (SQ) and one large cell carcinoma (LA), from 30 patients with non-small cell lung cancer (NSCLC) (18 AD, 10 SQ, and 2 LA), mainly in SCID hairless outbred (SHO) mice (Crlj:SHO-Prkdc^scid Hr^hr ). Histology of SQ, advanced clinical stage (III-IV), status of lymph node metastasis (N2-3), and maximum standardized uptake value ≥10 when evaluated using a delayed ¹⁸ F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scan was associated with successful PDX establishment. Histological analyses show

SUBMITTER: Kita K 

PROVIDER: S-EPMC6778641 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature