Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements.

ABSTRACT: Transdermal drug delivery provides several advantages over conventional drug administration, such as the avoidance of first-pass metabolism and better patient compliance. In vitro research can abbreviate and facilitate the pharmaceutical development considerably compared to in vivo research as drug screening and clinical studies can be reduced. These advantages led to the development of corresponding skin models. Viable skin models are more useful than non-viable ones, due to the influence of skin metabolism on the results. While most in vitro studies concentrate on evaluating human-based models, the current study is designed for the investigation of both human and animal diseases. So far, there is little information available in the literature about viable animal skin

SUBMITTER: Bauhammer I 

PROVIDER: S-EPMC6778665 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature