Screening and identification of biomarkers associated with clinicopathological parameters and prognosis in oral squamous cell carcinoma.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is a major type of malignant tumor of the oral cavity. Despite marked advances in the management and diagnosis of OSCC, the associated overall survival ratio has only exhibited a modest increase in recent years. The present study aimed to identify potential crucial genes associated with clinical features and prognosis for OSCC, and to provide a basis for further investigation. RNA-sequencing data and corresponding clinical information were downloaded from The Cancer Genome Atlas database and differentially expressed mRNAs (DEmRNAs) were identified using the edgeR package. Bioinformatics analysis was performed to identify differentially expressed clinical features-associated mRNAs (CFmRNAs) and enhance the current knowledge of the function of them. Functi

SUBMITTER: Wu Q 

PROVIDER: S-EPMC6778814 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature