LINC00460 Hypomethylation Promotes Metastasis in Colorectal Carcinoma.

ABSTRACT: Introduction: Epigenetic alterations and aberrantly expressed long noncoding RNAs (lncRNAs) are pervasive in colorectal cancer (CRC) tumorigenesis. DNA methylation could control lncRNA expression and play an important role in tumor initiation and progression. However, the DNA methylation that regulates lncRNAs in CRC remains poorly characterized. Materials and Methods: In our research, we integrated dysregulated expression and methylation of lncRNAs between colorectal tumor and adjacent mucosa tissues from The Cancer Genome Atlas database. With the use of this strategy, LINC00460, the most frequently epigenetically activated, was identified and further verified in the Cancer Cell Line Encyclopedia and Gene Expression Omnibus databases. Results: Patients with high expression of LINC00460 ar

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6779110 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature