Selective Hepatitis B Birth-Dose Vaccination in Sao Tome and Principe: A Program Assessment and Cost-Effectiveness Study.

ABSTRACT: São Tomé and Príncipe (STP) uses a selective hepatitis B birth-dose vaccination (HepB-BD) strategy targeting infants born to mothers who test positive for hepatitis B virus (HBV) surface antigen. We conducted a field assessment and economic analysis of the HepB-BD strategy to provide evidence to guide development of cost-effective policies to prevent perinatal HBV transmission in STP. We interviewed national stakeholders and key informants to understand policies, knowledge, and practices related to HepB-BD, vaccine management, and data recording/reporting. Cost-effectiveness of the existing strategy was compared with an alternate approach of universal HepB-BD to all newborns using a decision analytic model. Incremental cost-effectiveness ratios (ICERs) were calculated in 2015 USD per HBV-a

SUBMITTER: Hagan JE 

PROVIDER: S-EPMC6779202 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature