Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

ABSTRACT:

Background

Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown.

Methods

To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. Through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes. We used a spectrum of ten diabetic kidney disease definitions based on albuminuria and renal function.

Results

Our GWAS meta-analysis included association results for up to 19,406 individuals of European descent with type 1 diabetes. We iden

SUBMITTER: Salem RM 

PROVIDER: S-EPMC6779358 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature