Tissue-Resident Macrophages Promote Renal Cystic Disease.

ABSTRACT:

Background

Mutations affecting cilia proteins have an established role in renal cyst formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction occurs and whether the kidney has been injured. Disruption of cilia function before postnatal day 12-14 results in rapid cyst formation; however, cyst formation is slower when cilia dysfunction is induced after postnatal day 14. Rapid cyst formation can also be induced in conditional adult cilia mutant mice by introducing renal injury. Previous studies indicate that macrophages are involved in cyst formation, however the specific role and type of macrophages responsible has not been clarified.

Methods

We analyzed resident macrophage number and subtypes during postnatal renal maturation and after

SUBMITTER: Zimmerman KA 

PROVIDER: S-EPMC6779366 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature