Interaction between Streptococcus pneumoniae and Staphylococcus aureus Generates ^·OH Radicals That Rapidly Kill Staphylococcus aureus Strains.

ABSTRACT: Streptococcus pneumoniae rapidly kills Staphylococcus aureus by producing membrane-permeable hydrogen peroxide (H₂O₂). The mechanism by which S. pneumoniae-produced H₂O₂ mediates S. aureus killing was investigated. An in vitro model that mimicked S. pneumoniae-S. aureus contact during colonization of the nasopharynx demonstrated that S. aureus killing required outcompeting densities of S. pneumoniae Compared to the wild-type strain, isogenic S. pneumoniae ΔlctO and S. pneumoniae ΔspxB, both deficient in production of H₂O₂, required increased density to kill S. aureus While residual H₂O₂ activity produced by

SUBMITTER: Wu X 

PROVIDER: S-EPMC6779455 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature