Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

ABSTRACT: Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness¹, affecting 0.9-4% of women and 0.3% of men^2-4, with twin-based heritability estimates of 50-60%⁵. Mortality rates are higher than those in other psychiatric disorders⁶, and outcomes are unacceptably poor⁷. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)^8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with

SUBMITTER: Watson HJ 

PROVIDER: S-EPMC6779477 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature