On Information Extraction and Decoding Mechanisms Improved by Noisy Amplification in Signaling Pathways.

ABSTRACT: The cells need to process information about extracellular stimuli. They encode, transmit and decode the information to elicit an appropriate response. Studies aimed at understanding how such information is decoded in the signaling pathways to generate a specific cellular response have become essential. Eukaryotic cells decode information through two different mechanisms: the feed-forward loop and the promoter affinity. Here, we investigate how these two mechanisms improve information transmission. A detailed comparison is made between the stochastic model of the MAPK/ERK pathway and a stochastic minimal decoding model. The maximal amount of transmittable information was computed. The results suggest that the decoding mechanism of the MAPK/ERK pathway improve the channel capacity because it

SUBMITTER: Vazquez-Jimenez A 

PROVIDER: S-EPMC6779762 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature