LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer.

ABSTRACT: In recent years, long non-coding RNAs have emerged as a novel class of regulators of cancer biological processes. While they are dysregulated in many cancer types, little is known about their expression and functional profiles. This study has been focused on the determination of the role of a specific lncRNA in papillary thyroid cancer. Quantitative reverse transcription PCR was performed to detect the expression levels of 84 lncRNAs in 61 papillary thyroid carcinoma tissues and their adjacent non-tumor tissues. The highest fold-change was obtained for lung cancer associated transcript 1 LUCAT1, and thus, this study determines the expression and biological implication of lncRNA LUCAT1 through different in vitro and ex vivo approaches in this tumor. LUCAT1 was specifically located at the ce

SUBMITTER: Luzon-Toro B 

PROVIDER: S-EPMC6779763 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature