Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila.

ABSTRACT: It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrie

SUBMITTER: Zhao B 

PROVIDER: S-EPMC6779902 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature